Reasons Why PBMCs Are Needed for Medical Research Studies
When it comes to the chemicals, drugs, and personal care products that will be exposed to any living organisms, an in-depth toxicity evaluation as well as medical research studies must be done. One of key components of evaluating the toxicity levels of these products include making an assessment of the possible adverse effects they have on the immune system. It seems that because of the recent opinion of the public as well as ethical considerations, more efforts are directed towards the reduction of animals that are used to test how toxic drugs, personal products, and chemicals are. But then, there is only very little effort that is being done when there is a need to develop in silico and in vitro methods to be able to learn about immune dysfunctions. This is probably directed by the fact that the immune system in itself is complex on its own. Nevertheless, a lot of progress is being made when it comes to the medical research of these matters in more ways than one. This is the part where the role of PBMCs comes into the picture and why they are needed now. Understanding the importance of PBMCs in medical research is a must before you will go and buy PBMCs.
Any blood cell in the body that comes with a round nucleus such as lymphocyte, macrophage, and monocyte can be considered to be referred to as peripheral blood mononuclear cells or PMBCs. When it comes to your immune system, these blood cells will be able to adapt to any intruders and be able to fight infection better. From the whole blood, these cells can be extracted using Ficoll that is capable of separating the blood layers. Gradient centrifugation must then be done that will be able to separate the blood further into a top layer that is comprised of plasma and the lower layer that is comprised of PMBCs. For both medical research and toxicology purposes, the use of PMBCs has become very rampant. Since peripheral blood is where chemical exposure occurs, these PMBCs are easily affected by chemicals and drugs. These are some of the reasons why PMBCs are a key component for researchers to determine the toxicity levels of chemical compounds and new drugs. There are a lot of uses of PMBCs in doing medical research that is why researchers make sure to buy PMBCs.
One of the reasons why researchers must buy PMBCs is for them to do a new compound toxicity assessment. They help to answer questions pertaining to the toxicity of new drug compounds and their effect on the immune system of an individual. Life-threatening side effects can be expected when there is drug toxicity directed towards these PMBCs. Using PMBCs is thus essential for researchers to find out about the new drug compound dosage limit that they are studying.